Background: Imatinib mesylate (IM) resistance is an emerging problem for chronic myeloid
leukemia (CML). Previous studies found that connexin 43 (Cx43) deficiency in the …

Drug resistance remains a major challenge for multiple myeloma (MM) treatment, and side
population (SP) cells may play a key role in this resistance. The function of connexin 43 …

We recently reported that Cx43 expression and gap junction intercellular communication
(GJIC) between acute leukemic bone marrow stromal cells (BMSCs) were deficient, which …

Imatinib (IM) resistance could have significant impact on the survival time of the CML-
patients treated with IM. Previous studies have shown that the protective effects of the bone …

Gap junction intercellular communication (GJIC) among bone marrow stromal cells (BMSCs)
most frequently occurs through a channel composed of connexin43 (Cx43). Dysregulation of …

Objective To investigate the effect of gap junction intercellular communication (GJIC)
combined by connexin43 (Cx43) and its signal to the biobehavior of multiple myeloma (MM) …

Cx43 expressed on bone marrow stromal cells plays an essential role in multiple myeloma
cell survival and drug resistance Page 1 Basic research Corresponding author: Prof …

Multiple myeloma (MM) cells accumulate mainly in the bone marrow (BM) and are closely
related to the BM microenvironment. Connexin-43 (Cx43) is the main connexin present in …

Abstract Connexin 43 (Cx43) induced apoptosis has been reported in solid tumors, but the
effect of Cx43 expressed by bone marrow stromal cells (BMSC) in leukemia has not been …

A β-catenin expression signature is associated with primary resistance to tyrosine kinase
inhibitors (TKIs)(McWeeney et al. 2010), but its role in TKI resistance is not completely …