Contact between bone marrow (BM) hematopoietic stem cells (HSC) and osteoblast/stromal
(OS) cells has been shown to be crucial in the regulation of hematopoiesis. However, very …

Even though the BCR-ABL tyrosine kinase inhibitor imatinib significantly improves the
prognosis of chronic myelogenous leukaemia (CML) patients, drug resistance is a major …

Imatinib (IM) is highly effective in treatment of chronic myeloid leukemia (CML) but does not
eliminate minimal residual disease (MRD), which remains a potential source of relapse. IM …

Background Gap junctional intercellular communication (GJIC) is typically decreased in
malignant tumors. Gap junction is not presented between hematopoietic cells but occurred …

Imatinib resistance remains the big hurdle for CML therapy. Previous study reveals that c-
myc is important for bcr–abl CML cell proliferation, while its role in imatinib resistance is …

Objective To construct a co-culture system of mesenchymal stem cells (MSC) and multiple
myeloma (MM) cells and investigate the alterations of connexin 43 (CX43) expression and …

Chronic myeloid leukemia (CML), BCR-ABL1-positive, is classified as a myeloproliferative
characterized by Philadelphia chromosome/translocation t (9; 22) and proliferating …

Background: Oxaliplatin (OXA)-based chemotherapy is critical in the management of
advanced hepatocellular carcinoma (HCC); however, acquired drug resistance has largely …

Bone marrow stromal cells (BMSCs) can promote the growth of Philadelphia chromosome-
positive (Ph+) acute lymphoblastic leukemia (ALL). Histone deacetylases (HDACs) play …

Background Drug resistance is an important cause of death for most patients with chronic
myeloid leukemia (CML). The bone marrow microenvironment is believed to be mainly …