[HTML][HTML] DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma

S Wei, J Xing, J Chen, L Chen, J Lv, X Chen… - Journal of Experimental …, 2024 - Springer
Background Lung cancer is a malignant tumor with the highest mortality worldwide.
Abnormalities in the ubiquitin proteasome system are considered to be contributed to lung …

A multidimensional pan‐cancer analysis of DCAF13 and its protumorigenic effect in lung adenocarcinoma

S Wei, K Lu, J Xing, W Yu - The FASEB Journal, 2023 - Wiley Online Library
DCAF13 is a substrate recognition protein in the ubiquitin‐proteasome system with
oncogenic effects in several malignant tumors. However, it is unclear that the relationship …

The overexpression and prognostic role of DCAF13 in hepatocellular carcinoma

J Cao, P Hou, J Chen, P Wang, W Wang… - Tumor …, 2017 - journals.sagepub.com
DDB1 and CUL4 associated factor 13 (DCAF13) is a protein coding gene located on
chromosome 8q22. 3, which is a hotspot amplified in various cancers. DCAF13 has been …

DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression

BQ Shan, XM Wang, L Zheng, Y Han, J Gao… - Cancer …, 2022 - Wiley Online Library
Evolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently
discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 …

Doxorubicin promotes breast cancer cell migration and invasion via DCAF13

Z Sun, D Zhou, J Yang, D Zhang - FEBS Open Bio, 2022 - Wiley Online Library
DDB1 and CUL4 associated factor 13 (DCAF13) is a substrate receptor in the CUL4‐DDB1
E3 ligase, and its expression is associated with the prognosis of certain cancers. In the …

[HTML][HTML] DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway

J Zhang, Y Shi, K Ding, W Yu, J He, B Sun - Journal of Experimental & …, 2024 - Springer
Background Hepatocellular carcinoma (HCC) is a fatal malignancy with poor prognosis due
to lack of effective clinical interference. DCAF1 plays a vital role in regulating cell growth and …

FAM111B, a direct target of p53, promotes the malignant process of lung adenocarcinoma

H Sun, K Liu, J Huang, Q Sun, C Shao… - OncoTargets and …, 2019 - Taylor & Francis
Purpose Lung adenocarcinoma (LUAD) is a main subtype of lung cancer, which is the
leading cause of cancer-related deaths. The five-year survival rates of lung cancer patients …

[HTML][HTML] DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4

B Feng, X Wang, D Qiu, H Sun, J Deng, Y Tan… - International Journal of …, 2024 - mdpi.com
Lung adenocarcinoma (LUAD) is the most prevalent and aggressive subtype of lung cancer,
exhibiting a dismal prognosis with a five-year survival rate below 5%. DEAD-box RNA …

[HTML][HTML] Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma

X Dong, Y Han, E Zhang, Y Wang, P Zhang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved developmental
program that has been implicated in tumorigenesis and confers metastatic properties upon …

[HTML][HTML] Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas

H Yan, L Bi, Y Wang, X Zhang, Z Hou, Q Wang… - Scientific reports, 2017 - nature.com
Many DDB1-CUL4 associated factors (DCAFs) have been identified and serve as substrate
receptors. Although the oncogenic role of CUL4A has been well established, specific DCAFs …