In vivo chemical cross-linking combined with LCMSMS of digested extracts (in vivo CX-MS)
can reveal stable and dynamic protein-protein interactions at proteome-wide scale and at …

Identification of dynamic protein–protein interactions at the peptide level on a proteomic
scale is a challenging approach that is still in its infancy. We have developed a system to …

Chemical cross-linking mass spectrometry identifies interacting surfaces within a protein
assembly through labeling with bifunctional reagents and identifying the covalently modified …

Chemical cross-linking (CX) of proteins in vivo or in cell free extracts followed by mass
spectrometric (MS) identification of linked peptide pairs (CXMS) can reveal protein-protein …

Chemical cross-linking in combination with LC-MS/MS (XL-MS) is an emerging technology
to obtain low-resolution structural (distance) restraints of proteins and protein complexes …

Protein interaction reporter (PIR) technology can enable identification of in vivo protein
interactions with the use of specialized chemical cross-linkers, liquid chromatography, and …

Knowledge of protein structures and protein-protein interactions is essential for
understanding biological processes. Chemical cross-linking combined with mass …

We developed an informatic method to identify tandem mass spectra composed of
chemically cross-linked peptides from those of linear peptides and to assign sequence to …

Quantitative measurement of chemically cross-linked proteins is crucial to reveal dynamic
information about protein structures and protein–protein interactions and how these are …

The increased interest in chemical cross-linking for probing protein structure and interaction
has led to a large increase in literature describing new cross-linkers and search programs …