To the Editor: Asthma is a complex and heterogeneous chronic airway inflammatory disease
with the involvement of environmental factors through epigenetic mechanisms. 1 …

Background Allergic inflammation is commonly observed in a number of conditions that are
associated with atopy including asthma, eczema and rhinitis. However, the genetic …

The environment appears to play an important role in causing asthma, as evidenced by
increased disease prevalence accompanied by geographical differences 1, 2 and a small …

The airway epithelium forms the interface between the inhaled environment and the lung.
The airway epithelium is dysfunctional in asthma and epigenetic mechanisms are …

Approximately 40% of asthmatics experience remission of asthma symptoms. A better
understanding of biological pathways leading to asthma remission may provide insight into …

Maternal asthma (MA) is among the most consistent risk factors for asthma in children.
Possible mechanisms for this observation are epigenetic modifications in utero that have …

Asthma is a complex disease that is heritable (1); however, common genetic variants explain
a small portion of asthma risk (2). Epigenetic changes are influenced by the environment (3) …

The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …

Background DNA methylation of cytosines at CpG dinucleotides is a widespread epigenetic
mark; but genome-wide variation has been relatively unexplored due to the limited …

Epigenetic changes including DNA methylation caused by environmental exposures may
contribute to the heterogeneous inflammatory response in asthma. Here we investigate …