Glioblastoma multiforme is the most common malignant primary brain tumor in adults.
Histone H3 mutations have been identified in pediatric and adult gliomas, with H3K27M …

Background The 2016 WHO classification described a subtype of midline gliomas harboring
histone 3 (H3) K27M alterations, and the 2021 edition added a new subtype of hemispheric …

Mutations in histone H3 are key molecular drivers of pediatric and young adult high-grade
gliomas. Histone H3 G34R mutations occur in hemispheric high-grade gliomas and H3 …

Background" Diffuse midline glioma H3K27M-mutant"(a mutation gene encoding H3 histone
variants) represents a defined pathologic entity since the 2016 World Health Organization …

Background and purpose Molecular alterations were recently added to the World Health
Organization (WHO) 2016 classification of central nervous system (CNS) tumors. We …

METHODS This is a retrospective study of patients with H3K27M/I diffuse midline gliomas at
MSKCC from 01/2012 to 01/2019. Mutations were identified through next-generation …

A surprising theme that has emerged from sequencing the cancer genome is that mutations
in genes encoding histone proteins are very common. Histones bind DNA to form bead-like …

Adult cerebellar high-grade gliomas (HGG) are rare and their molecular basis has not been
fully elucidated. Although a diffuse midline glioma H3 K27M-mutant, a recently characterized …

Diffuse midline glioma with histone H3 lysine27-to-methionine mutation (H3 K27M mutation)
is a rare, aggressive tumor that is designated as World Health Organization (WHO) grade IV …

BACKGROUND AND PURPOSE: The 2016 World Health Organization Classification of
Tumors of the Central Nervous System includes “diffuse midline glioma with histone H3 …