Background Observational studies have shown a causal association between dyslipidemia
and osteoporosis, but the genetic causation and complete mechanism of which are …

ABSTRACT DNA methylation affects expression of associated genes and may contribute to
the missing genetic effects from genome-wide association studies of osteoporosis. To …

By adopting the extension approaches of Mendelian randomization, we successfully
detected and prioritized the potential causal risk factors for BMD traits, which might provide …

Both genetic and environmental factors are involved in the pathogenesis of osteoporosis
and other skeletal disorders. Epidemiological studies have revealed an influence of a variety …

Osteoporosis is mainly characterized by low bone mineral density (BMD) and is an
increasingly serious public health concern. DNA methylation is a major epigenetic …

The level of serum lipids is associated with bone mineral density (BMD), an important
skeletal trait. Yet the causality has not been determined. Here we performed a Mendelian …

Genetic and environmental determinants of skeletal phenotypes such as bone mineral
density (BMD) may converge through the epigenome, providing a tool to better understand …

Background Low-density lipoprotein cholesterol (LDL-C) is suggested to play a role in
osteoporosis but its association with bone metabolism remains unclear. Effects of LDL-C …

Osteoporosis is a complex non-communicable disease, known as a silent disease,
characterized by low bone mass and increased risk of fracture in multiple sites of the body …

Background The impact of lipid metabolism on bone metabolism remains controversial, and
the extent to which human traits mediate the effects of lipid metabolism on bone metabolism …