Context Osteoporosis is a metabolic bone disease. The effect of blood metabolites on the
development of osteoporosis remains elusive. Objective To explore the relationship …

Osteoporosis is a common form of metabolic bone disease that is costly to treat and is
primarily diagnosed on the basis of bone mineral density. As the influences of genetic …

Purpose Osteoporosis is associated with metabolic alterations, but the causal roles of serum
metabolites on osteoporosis have not been identified. Methods Based on the large …

Introduction Although there is a documented social gradient for osteoporosis, the underlying
mechanism (s) for that gradient remain unknown. We propose a conceptual model based …

To explore the association between lipid markers and osteoarthritis (OA). First, the National
Health and Nutrition Examination Survey (NHANES) database was used to screen …

Osteoarthritis (OA) imposes an increasing social burden due to global activity limitations,
especially among the aged. Links between circulating lipids and OA have been reported; …

Background Osteoporosis and cardiovascular diseases (CVDs) are 2 major public health
problems. Osteoporosis and CVDs may be linked but the association between lipid profile …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

Background: Cardiovascular disease (CVD) may have some association with osteoporosis
(OP). This Mendelian randomization (MR) investigation aimed to explore the potential …

Background Hypercholesterolemia and the related inflammatory response promote the
development of osteoporosis, but whether targeted interventions are protective against this …