Abstract Kadir et al.([1]) examined HB-glucose TCA cycle interactions under the hypothesis
that glucose metabolism would be necessary to support HB oxidation due to the ability of …

In heart, glucose and glycolysis are important for anaplerosis and potentially therefore for d‐
β‐hydroxybutyrate (βHB) oxidation. As a glucose store, glycogen may also furnish …

While the heart is a 'metabolic omnivore', the predominant sources of energy production are
fatty acid and glucose/lactate catabolism (Stanley et al. 2005). Cardiomyocytes can also …

The ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds
derived principally from fatty acids, that can be metabolised by many oxidative tissues …

Blood ketone body levels increase during starvation and untreated diabetes. Here we tested
the hypothesis that ketone bodies directly inhibit insulin action in skeletal muscle. We …

Aims Ketones have been proposed to be a 'thrifty'fuel for the heart and increasing cardiac
ketone oxidation can be cardioprotective. However, it is unclear how much ketone oxidation …

Abstract β-hydroxybutyrate is the primary ketone body produced by the body during ketosis
and is used to meet its metabolic demands. The healthy adult heart derives most of its …

Growing evidence suggests that the utilization of ketone bodies increases in the heart during
hypertrophy and heart failure; however, how the increased utilization of ketone bodies …

By directly measuring ketone oxidation rates in the mouse heart, we showed that ketone
oxidation contributes 15-20% of the total cardiac ATP production (Fig. However, a recent …

Interest in the myocardial effects of exogenous ketones in both healthy and disease states
has grown significantly in recent years. 1 The human myocardium requires 35 L of oxygen to …