New method and characterization of self-assembled gelatin–oleic nanoparticles using a desolvation method via carbodiimide/N-hydroxysuccinimide (EDC/NHS) …
In this study, we investigated a new method for the preparation of gelatin–oleic conjugate
(GOC) as an amphiphilic biomaterial to load model anti-cancer drugs into self-assembled …
(GOC) as an amphiphilic biomaterial to load model anti-cancer drugs into self-assembled …
Avidin-Biotin functionalized self-assembled protein nanoparticles as EGFR targeted therapeutics for the treatment of lung cancer: characterization and cell viability
Gefitinib targeting efficiency can be modified via enhancing its hydrophobicity and poor
bioavailability by conjugating it with biotin-streptavidin conjugated Bovine serum albumin …
bioavailability by conjugating it with biotin-streptavidin conjugated Bovine serum albumin …
[HTML][HTML] Development and evaluation of multifunctional poly (lactic-co-glycolic acid) nanoparticles embedded in carboxymethyl β-glucan porous microcapsules as a …
X Li, J Wang, S Li, Z Liu, Z Zheng, Y Zhang - Pharmaceutics, 2019 - mdpi.com
In this study, a new kind of folic acid (FA)-conjugated and chitosan (CS)-coated poloxamer
407 (P407)/poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs), FCPP NPs, were …
407 (P407)/poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs), FCPP NPs, were …
Curcumin-Loaded Chitosan-Coated 5-Fluorouracil Encapsulated Nanozeolitic Imidazolate Framework for Combination Cancer Therapy
JK Radhakrishnan, S Suma, AS Nair… - Journal of …, 2023 - Springer
Abstract Background 5-Fluorouracil (5-FU) is a good anti-cancer drug, but its prolonged use
results in overexpression of certain enzymes like thymidylate synthase and causes multidrug …
results in overexpression of certain enzymes like thymidylate synthase and causes multidrug …
A quality by design approach on polymeric nanocarrier delivery of gefitinib: formulation, in vitro, and in vivo characterization
NS Kola Srinivas, R Verma, G Pai Kulyadi… - International journal of …, 2017 - Taylor & Francis
Gefitinib is an anticancer agent which acts by inhibiting epidermal growth factor receptor
tyrosine kinase receptors. The aim of the present study was to prepare gefitinib …
tyrosine kinase receptors. The aim of the present study was to prepare gefitinib …
Facile construction of gefitinib‐loaded zeolitic imidazolate framework nanocomposites for the treatment of different lung cancer cells
K Aiyasamy, M Ramasamy, AH Hirad… - Biotechnology and …, 2024 - Wiley Online Library
Gefitinib (GET) is a revolutionary targeted treatment inhibiting the epidermal growth factor
receptor's tyrosine kinase action by competitively inhibiting the ATP binding site. In …
receptor's tyrosine kinase action by competitively inhibiting the ATP binding site. In …
Enhanced gefitinib cytotoxicity in the presence of cyclodextrins: in-vitro and biophysical studies towards potential therapeutic interventions for cancer
Gefitinib (Iressa®) is an inhibitor of EGFR tyrosine kinase, used in the treatment of lung and
other cancers. Its efficient use is severely hampered by very low solubility in water which can …
other cancers. Its efficient use is severely hampered by very low solubility in water which can …
Ligand-conjugated pH-sensitive polymeric micelles for the targeted delivery of gefitinib in lung cancers
SJ Wang, ZJ Huo, K Liu, N Yu, Y Ma, YH Qin, XC Li… - RSC Advances, 2015 - pubs.rsc.org
The aim of the present study was to investigate the tumor targeting potential of a mannose-
conjugated pH-sensitive nanosystem for the effective delivery of gefitinib (Gnb) to lung …
conjugated pH-sensitive nanosystem for the effective delivery of gefitinib (Gnb) to lung …
Intracellular targeted co-delivery of shMDR1 and gefitinib with chitosan nanoparticles for overcoming multidrug resistance
X Yu, G Yang, Y Shi, C Su, M Liu, B Feng… - International journal of …, 2015 - Taylor & Francis
Nowadays, multidrug resistance and side effects of drugs limit the effectiveness of
chemotherapies in clinics. P-glycoprotein (P-gp)(MDR1), as a member of the ATP-binding …
chemotherapies in clinics. P-glycoprotein (P-gp)(MDR1), as a member of the ATP-binding …
The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation
To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs)
as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side …
as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side …