Epithelial–mesenchymal transition (EMT) in cancer promotes metastasis and chemotherapy
resistance. A subset of triple-negative breast cancer (TNBC) exhibits a mesenchymal gene …

Simple Summary Protein ubiquitination is catalyzed by many enzymes, whose functions and
substrate specificity are not fully understood. This study reports the expression patterns of …

Patients with triple-negative breast cancers (TNBC) are at high risk for recurrent or
metastatic disease despite standard treatment, underscoring the need for novel therapeutic …

Background Human MARCH5 is a mitochondrial localized E3 ubiquitin-protein ligase that is
critical for the regulation of mitochondrial dynamics. A body of evidence has indicated the …

Metastasis of breast cancer is promoted by epithelial–mesenchymal transition (EMT).
Emerging evidence suggests that STAT 3 is a critical signaling node in EMT and is …

Abstract Mixed-lineage kinase 3 (MLK3), a mitogen-activated kinase kinase kinase
(MAP3K), contributes to metastasis of triple-negative breast cancer (TNBC), in part through …

Abstract Mixed-lineage kinase 3 (MLK3), a mitogen-activated protein kinase kinase kinase
(MAP3K), has critical roles in metastasis of triple-negative breast cancer (TNBC), in part by …

The mammalian STE 20-like protein kinase 4 (MST4) gene is highly expressed in several
cancer types, but little is known about the role of MST4 in breast cancer, and the function of …

Triple‐negative breast cancer (TNBC) presents a clinical challenge due to the aggressive
nature of the disease and a lack of targeted therapies. Constitutive activation of the mitogen …

Abstract Epithelial/Mesenchymal (E/M) plasticity plays a fundamental role both in
embryogenesis and during tumorigenesis. The receptor for advanced glycation end …