Rationale Asthma has substantial morbidity and mortality and a strong genetic component,
but identification of genetic risk factors is limited by availability of suitable studies. Objectives …

This review focuses on genome-wide association studies (GWASs) of asthma and allergic
diseases published between January 1, 2018, and June 30, 2019. During this time period …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Asthma is a chronic and genetically complex respiratory disease that affects over 300 million
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …

Background Asthma and allergy are complex multifactorial disorders, with both genetic and
environmental components determining disease expression. The use of molecular genetics …

The next wave of asthma genetic studies will use full-genome sequencing and overcome
most GWAS-associated problems. It will be the last step of a century-long search for asthma …

Background Genomewide association studies (GWAS s) of asthma have identified single‐
nucleotide polymorphisms (SNP s) that modestly increase the risk for asthma. This could be …

Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …

(NHGRI) Catalog revealed 113 suggestive associations (P< 1 3 10 205)(see Table E2 in this
article's Online Repository at www. jacionline. org). Of these, 87 SNPs (77%) were also …

Background Genome-wide association studies (GWAS) have discovered genetic variants
that predispose individuals to asthma. To integrate these new discoveries with emerging …