Cardiac fibrosis is a significant component of pathological heart remodeling, yet it is not
directly targeted by existing drugs. Systems pharmacology approaches have the potential to …

Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the
uncontrolled accumulation of extracellular matrix proteins, which can exacerbate the …

Background and Purpose Pathological cardiomyocyte hypertrophy is a response to cardiac
stress that typically leads to heart failure. Despite being a primary contributor to pathological …

Altered fibroblast behavior can lead to pathologic changes in the heart such as arrhythmia,
diastolic dysfunction, and systolic dysfunction. Computational models are increasingly used …

Cardiac fibroblasts support heart function, and aberrant fibroblast signaling can lead to
fibrosis and cardiac dysfunction. Yet how signaling molecules drive myofibroblast …

Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the
uncontrolled accumulation of extracellular matrix proteins which can exacerbate the …

Mechanical strain is a potent stimulus for growth and remodeling in cells. Although many
pathways have been implicated in stretch-induced remodeling, the control structures by …

As a result of stress, injury, or aging, cardiac fibrosis is characterized by excessive
deposition of extracellular matrix (ECM) components resulting in pathological remodeling …

Fibroblasts are essential regulators of extracellular matrix deposition following cardiac
injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response …

Pulmonary fibrosis is pathologic remodeling of lung tissue that can result in difficulty
breathing, reduced quality of life, and a poor prognosis for patients. Fibrosis occurs as a …