Transforming growth factor β receptor (TGF-β1R) and receptor tyrosine kinases (RTKs), such
as VEGFRs, PDGFRs and FGFRs are considered important therapeutic targets in blocking …

Abstract Angiotensin II (Ang II) presents a critical mediator in various pathological conditions
such as non-genetic cardiomyopathy. Osmotic pump infusion in rodents is a commonly used …

Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-
throughput omics techniques have generated vast amounts of genotypic and molecular …

Regional control of fibrosis after myocardial infarction is critical for maintaining structural
integrity in the infarct while preventing collagen accumulation in non-infarcted areas …

A fundamental process in the development and progression of heart failure is fibrotic
remodeling, characterized by excessive deposition of extracellular matrix proteins in …

Background: Myocardial fibrosis is a hallmark of cardiac remodeling and functionally
involved in heart failure development, a leading cause of deaths worldwide. Clinically, no …

Fibrosis, a progressive accumulation of extracellular matrix components, encompasses a
wide spectrum of distinct organs, and accounts for an increasing burden of morbidity and …

Myocardial fibrosis (MF) is the manifestation of a variety of cardiovascular diseases.
Salidroside (SAL) has been proved to have a certain effect on anti-fibrosis in various organs …

Systems pharmacology aims to holistically understand mechanisms of drug actions to
support drug discovery and clinical practice. Systems pharmacology modeling (SPM) is data …

Cardiac fibrosis is insidious, accelerating cardiovascular diseases, heart failure, and death.
With a notable lack of effective therapies, advances in both understanding and targeted …