Abstract Hypoxia-inducible Factor 1 (HIF-1) is a transcriptional activator that intervenes in
versatile reactions to hypoxia. Natural drugs, widely distributed in plants, comprise many …

Hypoxia-inducible factor-1 alpha (HIF-1α) is overexpressed in cancer, leading to a poor
prognosis in patients. Diverse cellular factors are able to regulate HIF-1α expression in …

The discovery of hypoxia-inducible factor-1 has led to a rapidly increasing understanding of
the molecular mechanism of tumor hypoxia in the past two decades. Today it is generally …

The transcription factor hypoxia-inducible factor-1 (HIF-1) regulates the expression of more
than 70 genes involved in cellular adaptation and survival under hypoxic stress. Activation of …

Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major
subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of …

A decline in the tissue oxygen level below normal leads to cellular hypoxia. This situation is
very frequently encountered in solid tumors as existing blood vessels cannot satisfy the …

Rapid progress in molecular cancer biology coupled with the discovery of novel oncology
drugs has opened new horizons for cancer target discovery. As one of the crucial signaling …

Cancer remains a critical study since long period. Inspite of remarkable development in
science, still suitable cure and treatment is not available. In humans, Hypoxia-inducible …

Tumor cells are often exposed to hypoxia because of the lower oxygen supply deep inside
the tumor tissues. However, tumor cells survive in these severe conditions by adapting to …

Tumor hypoxia has been recognized as a common feature of solid tumors and a negative
prognostic factor for response to treatment and survival of cancer patients. The discovery of …