Purpose: Rooibos (RB) has been reported to confer cardioprotection, but the underlying
mechanisms are not fully elucidated. Furthermore, RB has never been tested againstcardiac …

Calpain-1 activation and oxidative stress are two critical factors contributing to apoptosis of
hypertrophic cardiomyocyte. Astragaloside IV (ASIV) exhibits protective effect against …

Background Our previous studies have demonstrated that Ang II induced IGF-II and IGF-II R
via ERK and JNK signaling pathways and further induces cardiac cell apoptosis. Purpose …

Araloside C (AsC) has potential cardioprotective properties. However, the underlying
mechanism of AsC-mediated cardioprotection, especially the role of mitochondrial function …

Astragaloside is one of the most common traditional Chinese medicines and is derived from
Astragalus membranaceus. Astragaloside IV (AsIV) is a monomer located in an extract of …

Mitochondrial dysfunction plays a critical role in the development of cardiac hypertrophy and
heart failure. So mitochondria are emerging as one of the important druggable targets in the …

Background Mitochondrial dysfunction and subsequent cardiomyocyte apoptosis
significantly contribute to pressure overload-induced heart failure (HF). A highly oxidative …

Angiotensin II (Ang II) is a risk factor for cardiovascular disease. We used a traditional
Chinese medicine, alpinate oxyphyllae fructus (AOF), to evaluate its effect on Ang II-induced …

This study aimed to determine the effects of Bauhinia championii flavone (BCF) on hypoxia-
reoxygenation (H/R) induced apoptosis in H9c2 cardiomyocytes and to explore potential …

Myocardial ischemia/reperfusion (I/R) injury is a common cardiovascular disease with high
morbidity and mortality globally, which derives from acute myocardial infarction and …