Due to its aggressive and invasive nature glioblastoma (GBM), the most common and
aggressive primary brain tumour in adults, remains almost invariably lethal. Significant …

Gliomas are the most common type of primary brain tumour and are often fast growing with a
poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and …

Glioblastoma Multiforme (GBM) is the most common and lethal of human primary central
nervous system (CNS) tumors, with a median survival of 14-16 months despite optimal …

An increasing body of evidence suggests that astrocytic gliomas of the central nervous
system may be derived from gliotypic neural stem cells. To date, the study of these tumors …

Direct cellular reprogramming has recently gained attention of cancer researchers for the
possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell …

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …

Purpose To provide a critical assessment of current stem-cell based pre-clinical models of
astrocytomas (gliomas). Methods Data were archived from MEDLINE using Boolean …

Gliomas are malignant primary tumors of the central nervous system. Their cell-of-origin is
thought to be a neural progenitor or stem cell that acquires mutations leading to oncogenic …

Neural stem cells (NSCs) undergo self-renewal and generate neurons and glial cells under
the influence of specific signals from surrounding environments. Glioblastoma multiforme …

Malignant brain tumors, including glioblastoma multiforme (GBM), are known for their high
degree of invasiveness, aggressiveness, and lethality. These tumors are made up of …