Pediatric kidney transplantation is a lifesaving therapy for children with kidney failure. With
modern immunosuppression, transplant rejection is as low as 11% in the first year post …

Next-generation sequencing has dramatically decreased the cost of gene sequencing,
facilitating the simultaneous analysis of multiple genes at the same time; obtaining a genetic …

Rare kidney diseases are a unique subset of renal disorders that are often termed
'orphan'as a result of a multitude of reasons: the small number of patients with the …

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The clinical spectrum of monogenic renal diseases is wide ranging, from autosomal
dominant polycystic kidney disease to very rare inherited disorders. The genes involved in …

The risk of disease recurrence (DR) after renal transplantation (Tx) is relatively high in
children and may lead to graft loss (GL), representing 7–8% of all graft failures. Recurrence …

Genetic kidney disease is a common cause of kidney disease in adults, and one of the
commonest causes in children—often with devastating consequences, including end stage …

The primary cause of ESRD remains unresolved in 15%–20% of adult patients, a
percentage probably underestimated considering that the nonspecific diagnoses of …

Classification of the underlying renal disorder in kidney transplant patients involves some
uncertainties. To allow evaluation of the risk of recurrence of renal disease in the …

The cause of chronic kidney disease (CKD) remains unknown in at least 20% of patients. In
this thesis, we assessed the diagnostic value of genetic testing in adult patients with …