A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity

R Yang, Y Deng, B Huang, L Huang, A Lin… - Signal transduction and …, 2021 - nature.com
Although inoculation of COVID-19 vaccines has rolled out globally, there is still a critical
need for safe and effective vaccines to ensure fair and equitable supply for all countries …

A novel mRNA vaccine, SYS6006, against SARS-CoV-2

K Xu, W Lei, B Kang, H Yang, Y Wang, Y Lu… - Frontiers in …, 2023 - frontiersin.org
The development of vaccines that can efficiently prevent the infection of SARS-CoV-2 is
necessary to fight the COVID-19 epidemic. mRNA vaccine has been proven to induce strong …

A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models

G Maruggi, CP Mallett, JW Westerbeck, T Chen… - Molecular Therapy, 2022 - cell.com
RNA vaccines have demonstrated efficacy against SARS-CoV-2 in humans, and the
technology is being leveraged for rapid emergency response. In this report, we assessed …

[HTML][HTML] Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2

JT Granados-Riveron, G Aquino-Jarquin - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Currently, there are over 230 different COVID-19 vaccines under development around the
world. At least three decades of scientific development in RNA biology, immunology …

[HTML][HTML] mRNA vaccines for COVID-19: what, why and how

JW Park, PNP Lagniton, Y Liu… - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …

The dawn of mRNA vaccines: The COVID-19 case

R Verbeke, I Lentacker, SC De Smedt… - Journal of Controlled …, 2021 - Elsevier
In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based
vaccines, BNT162b2 and mRNA-1273, were granted the first historic authorization for …

mRNA vaccines for COVID-19 and diverse diseases

A Hussain, H Yang, M Zhang, Q Liu, G Alotaibi… - Journal of Controlled …, 2022 - Elsevier
Since its outbreak in late 2019, the novel coronavirus disease 2019 (COVID-19) has spread
to every continent on the planet. The global pandemic has affected human health and …

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

L Ai, Y Li, L Zhou, W Yao, H Zhang, Z Hu, J Han… - Cell Discovery, 2023 - nature.com
Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, most current
mRNA delivery platforms need to be stored at− 20° C or− 70° C due to their poor stability …

A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice

J Lu, G Lu, S Tan, J Xia, H Xiong, X Yu, Q Qi, X Yu, L Li… - Cell research, 2020 - nature.com
Dear Editor, Since the beginning of this century, humanity has been struck three times by the
coronavirus outbreak. The most recent one is caused by the SARS-CoV-2 virus, which was …

A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice

D Laczkó, MJ Hogan, SA Toulmin, P Hicks, K Lederer… - Immunity, 2020 - cell.com
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high
transmissibility of the virus and the high rate of morbidity and mortality associated with …