Placental growth factor in beta cells plays an essential role in gestational beta-cell growth

W Yang, Y Jiang, Y Wang, T Zhang, Q Liu… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Objective Pancreatic beta cells proliferate in response to metabolic requirements during
pregnancy, while failure of this response may cause gestational diabetes. A member of the …

Impaired proliferation of pancreatic beta cells, by reduced placental growth factor in pre‐eclampsia, as a cause for gestational diabetes mellitus

J Li, H Ying, G Cai, Q Guo, L Chen - Cell proliferation, 2015 - Wiley Online Library
Objectives Reduced increase in serum placental growth factor (PLGF) levels frequently
occurs in patients with pre‐eclampsia (PE) and thus has been used as a predictive factor for …

[HTML][HTML] Reduction in placental growth factor impaired gestational beta-cell proliferation through crosstalk between beta-cells and islet endothelial cells

X Xu, J Shen - American Journal of Translational Research, 2016 - ncbi.nlm.nih.gov
Reduced placental growth factor (PLGF) during pregnancy is known to be a reason for
developing preeclampsia (PE) and gestational diabetes mellitus (GDM), but the underlying …

Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2

B Zhao, J Cai, M Boulton - Microvascular research, 2004 - Elsevier
Placenta growth factor (PlGF) has been implicated in both physiological and pathological
angiogenesis; however, little is known about what regulates its expression. In this study …

[HTML][HTML] Pre-eclampsia-associated reduction in placental growth factor impaired beta cell proliferation through PI3k signalling

J Li, H Ying, G Cai, Q Guo, L Chen - Cellular Physiology and …, 2015 - karger.com
Background/Aim: Reduction in serum placental growth factor (PLGF) frequently co-occurs
with preeclampsia (PE) and gestational diabetes mellitus (GDM). Recently, we reported that …

Maternal serum placental growth factor and fetal SGA in pregnancy complicated by type 1 diabetes mellitus

P Gutaj, E Wender-Ożegowska, R Iciek… - Journal of Perinatal …, 2014 - degruyter.com
Aim: To analyze the role of maternal placental growth factor (PlGF) in the prediction of small
for gestational age (SGA) birth weight in pregnancy complicated by type 1 diabetes mellitus …

Time-specific placental growth factor (PlGF) across pregnancy and infant birth weight in women with preexisting diabetes

T James-Todd, A Cohen, J Wenger… - Hypertension in …, 2016 - Taylor & Francis
Objective: Determine the independent association between time-specific placental growth
factor (PIGF)—a marker of placental vasculature—and infant birth weight in offspring of …

[HTML][HTML] In vivo evidence of significant placental growth factor release by normal pregnancy placentas

AS Cerdeira, N Kandzija, P Pargmae, M Tome… - Scientific Reports, 2020 - nature.com
Placental growth factor (PlGF) is an angiogenic factor identified in the maternal circulation,
and a key biomarker for the diagnosis and management of placental disorders. Furthermore …

Relationship between elevated serum level of placental growth factor and status of gestational diabetes mellitus

U Gorkem, C Togrul, E Arslan - The Journal of Maternal-Fetal & …, 2020 - Taylor & Francis
Objective: As only limited and confusing evidence about serum placental growth factor
(PlGF) level in gestational diabetes mellitus (GDM) exist in the known literature, the aim of …

Streptozotocin-induced diabetes decreases placenta growth factor (PlGF) levels in rat placenta

PO Koh, JH Sung, CK Won, JH Cho… - Journal of Veterinary …, 2007 - jstage.jst.go.jp
The placenta produces several growth factors, including placenta growth factor (PlGF),
which are essential for placenta growth and fetal growth. Diabetic pregnancy induces the …