[HTML][HTML] Vascular Biology and Microcirculation: Cardiac epigenetic changes in VEGF signaling genes associate with myocardial microvascular rarefaction in …

A Eirin, AR Chade - American Journal of Physiology-Heart and …, 2023 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) is common in patients with heart failure and often results in
left ventricular diastolic dysfunction (LVDD). However, the mechanisms responsible for …

Cardiac epigenetic changes in VEGF signaling genes associate with myocardial microvascular rarefaction in experimental chronic kidney disease

A Eirin, AR Chade - American Journal of Physiology-Heart …, 2023 - journals.physiology.org
Chronic kidney disease (CKD) is common in patients with heart failure and often results in
left ventricular diastolic dysfunction (LVDD). However, the mechanisms responsible for …

MO421: Chronic Kidney Disease is Associated With Cardiac Downregulation of Vascular Endothelial Growth Factor a (VEGFA) and Development of Diastolic …

A Chade, A Eirin - Nephrology Dialysis Transplantation, 2022 - academic.oup.com
Abstract BACKGROUND AND AIMS Patients with chronic kidney disease (CKD) have a
higher risk to develop heart failure with preserved ejection fraction (HFpEF). We showed in a …

Myocardial epigenetic modifications link chronic kidney disease to coronary microvascular disease

P Sen, O Sorop, D Merkus - American Journal of …, 2023 - journals.physiology.org
The observation that patients with albuminous urine have an enlarged heart was already
published by Dr Richard Bright in 1836 (1). Since then, not only end-stage but also mild …

[HTML][HTML] Integrative Cardiovascular Physiology and Pathophysiology: Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease …

AR Chade, A Eirin - American Journal of Physiology-Heart and …, 2022 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) is an independent risk factor for the development of heart
failure, but the underlying mechanisms remain unknown. Using a novel translational swine …

[HTML][HTML] Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis

HU Prommer, J Maurer, K Von Websky, C Freise… - Scientific reports, 2018 - nature.com
Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular
disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently …

[HTML][HTML] Comparative Physiological Genomics: The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the …

SC Kelly, CD Rau, A Ouyang, PK Thorne… - Physiological …, 2021 - ncbi.nlm.nih.gov
Heart failure (HF) patients with deteriorating right ventricular (RV) structure and function
have a nearly twofold increased risk of death compared with those without. Despite the well …

[HTML][HTML] Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure

M Movassagh, MK Choy, M Goddard, MR Bennett… - PloS one, 2010 - journals.plos.org
Epigenetic mechanisms such as microRNA and histone modification are crucially
responsible for dysregulated gene expression in heart failure. In contrast, the role of DNA …

Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction

AR Chade, A Eirin - American Journal of Physiology-Heart …, 2022 - journals.physiology.org
Chronic kidney disease (CKD) is an independent risk factor for the development of heart
failure, but the underlying mechanisms remain unknown. Using a novel translational swine …

The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature

SC Kelly, CD Rau, A Ouyang… - Physiological …, 2021 - journals.physiology.org
Heart failure (HF) patients with deteriorating right ventricular (RV) structure and function
have a nearly twofold increased risk of death compared with those without. Despite the well …