Melatonin is primarily synthesized and secreted by the pineal gland during darkness in a
normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has …

Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal
gland and locally in the retina following a circadian rhythm, with low levels during the day …

Melatonin is a neurohormone that translates the circadian rhythm to the peripheral organs
through a series of binding sites identified as G protein‐coupled receptors MT1 and MT2 …

In mammals, melatonin activates melatonin MT1 and MT2 receptors. Using site-directed
mutagenesis and chemical modification, we investigated the role of conserved cysteines in …

Introduction: Melatonin is a neurohormone that controls many relevant physiological
processes beyond the control of circadian rhythms. Melatonin's actions are carried out by …

To better understand the mechanism of interactions between G-protein-coupled melatonin
receptors and their ligands, our previously reported homology model of human MT2 receptor …

The tryptophan derivative melatonin is an evolutionary old molecule that is involved in a
pleiotropy of physiological functions. In humans, age‐related decline of circulating melatonin …

Models of G protein-coupled melatonin receptor structure suggest that ligand recognition
occurs in a binding pocket formed by transmembrane helices III, V and VII. Constitutively …

Importance of the field: Increasing clinical evidences suggest that melatonin receptor
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …

Melatonin (5-methoxy-acetyl tryptamine) is a sleep-inducing hormone, and the pineal gland
produces it in response to the circadian clock of darkness. In the body, MT1 and MT2 …