Aquaporin-4 deficiency is associated with cognitive impairment and alterations in astrocyte-neuron lactate shuttle

H Cha, JH Choi, H Jeon, JH Kim, M Kim, SJ Kim… - Molecular …, 2023 - Springer
Cognitive impairment refers to notable declines in cognitive abilities including memory,
language, and emotional stability leading to the inability to accomplish essential activities of …

Distribution and possible roles of aquaporin 9 in the brain

J Badaut, L Regli - Neuroscience, 2004 - Elsevier
Aquaporin 9 (AQP9) is a member of the aquaporin channel family involved in water flux
through plasma membranes and exhibits the distinct feature of being also permeable to …

Aquaporins in the brain: from aqueduct to “multi-duct”

J Badaut, JF Brunet, L Regli - Metabolic Brain Disease, 2007 - Springer
The aquaporin channel family was first considered as a family of water channels, however it
is now clear that some of these channels are also permeable to small solutes such glycerol …

Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes

XN Zeng, XL Sun, L Gao, Y Fan, JH Ding… - Molecular and Cellular …, 2007 - Elsevier
The role of aquaporin-4 in water transport has been extensively investigated, while little
information exists regarding its contribution to astrocytic functions such as the action to …

The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory

JI Szu, DK Binder - Frontiers in integrative neuroscience, 2016 - frontiersin.org
Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the
central nervous system (CNS). AQP4 is widely expressed throughout the brain, especially at …

Aquaporin-4 promotes memory consolidation in Morris water maze

Y Fan, M Liu, X Wu, F Wang, J Ding, J Chen… - Brain Structure and …, 2013 - Springer
Abstract Aquaporin-4 (AQP4), the most abundant aquaporin in the brain, is polarized at the
glial end-feet facing peri-synaptic areas. AQP4 has been hypothesized to modulate water …

The Neuroprotective Effect of the Association of Aquaporin‐4/Glutamate Transporter‐1 against Alzheimer's Disease

YL Lan, S Zou, JJ Chen, J Zhao, S Li - Neural Plasticity, 2016 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by memory loss and cognitive dysfunction. Aquaporin‐4 (AQP4), which is primarily …

Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice

T Pavlin, EA Nagelhus, C Brekken, EM Eyjolfsson… - Neurochemical …, 2017 - Springer
The first aim of this study was to determine how complete or perivascular loss of aquaporin-4
(AQP4) water channels affects membrane permeability for water in the mouse brain grey …

[HTML][HTML] Aquaporin-4 and cognitive disorders

Y Wang, C Huang, Q Guo, H Chu - Aging and disease, 2022 - ncbi.nlm.nih.gov
Abstract Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central
nervous system (CNS) and is an integral part of the glymphatic system that cannot be …

Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection

L Liu, Y Lu, H Kong, L Li, C Marshall… - International Journal …, 2012 - academic.oup.com
Astrocyte dysfunction is implicated in pathogenesis of certain neurological disorders
including Alzheimer's disease (AD). A growing body of evidence indicates that water …