Human red blood cells modulate cytokine expression in monocytes/macrophages under anoxic conditions
A Antonelli, ES Scarpa, M Magnani - Frontiers in Physiology, 2021 - frontiersin.org
In the bone marrow (BM) hematopoietic niche, the oxygen tension is usually very low. Such
condition affects stem and progenitor cell proliferation and differentiation and, at cellular …
condition affects stem and progenitor cell proliferation and differentiation and, at cellular …
Red blood cells induce hypoxic lung inflammation
R Kiefmann, JM Rifkind, E Nagababu… - Blood, The Journal …, 2008 - ashpublications.org
Hypoxia, which commonly associates with respiratory and cardiovascular diseases,
provokes an acute inflammatory response. However, underlying mechanisms are not well …
provokes an acute inflammatory response. However, underlying mechanisms are not well …
Red blood cells are dynamic reservoirs of cytokines
Red blood cells (RBCs) have been shown to affect immune function and can induce
inflammatory responses after transfusion. The transfusion of washed RBCs can significantly …
inflammatory responses after transfusion. The transfusion of washed RBCs can significantly …
Hematopoietic progenitor and stem cell regulation during development: hypoxia and niches
P Imanirad - 2013 - repub.eur.nl
In a healthy adult person, almost 1011-1012 new blood cells are generated daily in order to
maintain the steady state in peripheral circulation (Paul, 2008). To this end, a high level of …
maintain the steady state in peripheral circulation (Paul, 2008). To this end, a high level of …
Phenotypic Alterations in Erythroid Nucleated Cells of Spleen and Bone Marrow in Acute Hypoxia
K Nazarov, R Perik-Zavodskii, O Perik-Zavodskaia… - Cells, 2023 - mdpi.com
Hypoxia leads to metabolic changes at the cellular, tissue, and organismal levels. The
molecular mechanisms for controlling physiological changes during hypoxia have not yet …
molecular mechanisms for controlling physiological changes during hypoxia have not yet …
Evaluation of erythrocyte changes after normoxic return from hypoxia
Hypoxia increases erythropoiesis by hypoxia-inducible factors (HIF), principally by HIF-2,
which upregulates erythropoietin transcription. This results in an increase of red blood cell …
which upregulates erythropoietin transcription. This results in an increase of red blood cell …
Hyperbaric oxygen exposure temporarily reduces Mac-1 mediated functions of human neutrophils
J Kalns, J Lane, A Delgado, J Scruggs, E Ayala… - Immunology letters, 2002 - Elsevier
Highly elevated partial pressures of oxygen achievable during hyperbaric oxygenation
(HBO) have been shown to reduce leukocyte sequestration following ischemia/reperfusion …
(HBO) have been shown to reduce leukocyte sequestration following ischemia/reperfusion …
[HTML][HTML] Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro
Background In the bone marrow mesenchymal stromal cells and osteoblasts form functional
niches for hematopoietic stem and progenitor cells. This microenvironment can be partially …
niches for hematopoietic stem and progenitor cells. This microenvironment can be partially …
Regulation of whole blood polymorphonuclear leukocyte phagocytosis following hypoxemia and hypoxemia/reoxygenation
HH Simms, R D'Amico - Shock, 1994 - journals.lww.com
Phagocytosis of whole blood polymorphonuclear leukocytes (PMN) was evaluated following
periods of hypoxemia or hypoxemia/reoxygenation. Hypoxemia (O 2 saturation 5–20%) …
periods of hypoxemia or hypoxemia/reoxygenation. Hypoxemia (O 2 saturation 5–20%) …
Carbon monoxide induced erythroid differentiation of K562 cells mimics the central macrophage milieu in erythroblastic islands
S Toobiak, M Shaklai, N Shaklai - PLoS One, 2012 - journals.plos.org
Growing evidence supports the role of erythroblastic islands (EI) as microenvironmental
niches within bone marrow (BM), where cell-cell attachments are suggested as crucial for …
niches within bone marrow (BM), where cell-cell attachments are suggested as crucial for …