In the bone marrow (BM) hematopoietic niche, the oxygen tension is usually very low. Such
condition affects stem and progenitor cell proliferation and differentiation and, at cellular …

Hypoxia, which commonly associates with respiratory and cardiovascular diseases,
provokes an acute inflammatory response. However, underlying mechanisms are not well …

Red blood cells (RBCs) have been shown to affect immune function and can induce
inflammatory responses after transfusion. The transfusion of washed RBCs can significantly …

In a healthy adult person, almost 1011-1012 new blood cells are generated daily in order to
maintain the steady state in peripheral circulation (Paul, 2008). To this end, a high level of …

Hypoxia leads to metabolic changes at the cellular, tissue, and organismal levels. The
molecular mechanisms for controlling physiological changes during hypoxia have not yet …

Hypoxia increases erythropoiesis by hypoxia-inducible factors (HIF), principally by HIF-2,
which upregulates erythropoietin transcription. This results in an increase of red blood cell …

Highly elevated partial pressures of oxygen achievable during hyperbaric oxygenation
(HBO) have been shown to reduce leukocyte sequestration following ischemia/reperfusion …

Background In the bone marrow mesenchymal stromal cells and osteoblasts form functional
niches for hematopoietic stem and progenitor cells. This microenvironment can be partially …

Phagocytosis of whole blood polymorphonuclear leukocytes (PMN) was evaluated following
periods of hypoxemia or hypoxemia/reoxygenation. Hypoxemia (O 2 saturation 5–20%) …

Growing evidence supports the role of erythroblastic islands (EI) as microenvironmental
niches within bone marrow (BM), where cell-cell attachments are suggested as crucial for …