Background: Angiogenesis, involving the formation of new blood vessels from preexisting
vessels, caters an important biological phenomenon for the growth and development of …

Introduction: Angiogenesis was first proposed as a possible target for the treatment of
human cancer several decades ago. During recent years, the discovery of VEGF as the main …

Induction of angiogenesis represents one of the major hallmarks of cancer. The growth of
new vessels is crucial to provide malignant cells with an adequate supply of oxygen and …

Angiogenesis is defined as the physiological process by which new blood vessels develop
from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis …

Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have crucial roles in
both physiological and pathological angiogenesis. The VEGF family consists of VEGF-A …

Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …

Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …

Introduction: Angiogenesis is an important component of certain normal physiological
processes, but aberrant angiogenesis contributes to some pathological disorders and in …

A vast amount of data shows that angiogenesis has a pivotal role in tumor growth,
progression, invasiveness and metastasis. This is a complex process involving essential …

It has been recognized for decades that angiogenesis is an important event in tumor growth
and metastasis; the concept of the “angiogenic switch,” whereby tumors acquire the ability to …