Expression of the purinergic receptor P2RX7 by CD8+ T cells promotes generation of
memory populations following acute infections, but recent studies have indicated that …

Expression of the purinergic receptor P2RX7 by CD8+ T cells promotes the generation of
memory populations following acute infections. However, data suggest that P2RX7 may limit …

Extracellular ATP (eATP) is a signaling molecule that variably affects all cells of the immune
system either directly or after hydrolysis to adenosine. Although eATP is virtually absent in …

Background Extracellular adenosine triphosphate (eATP) is a 'danger signal'used to sense
cellular damage, and recognized by purinergic receptors in mammals. Among those …

While P2X7 receptor expression on tumour cells has been characterized as a promotor of
cancer growth and metastasis, its expression by the host immune system is central for …

P2X7 (also known as P2RX7) is a plasma membrane receptor for extracellular ATP that is
expressed at a high level by immune and tumor cells. Previous data showed that increased …

Brain cancer is the leading cause of cancer-related death in adults under the age of 40.
Glioblastomas are the most common and aggressive form. This thesis examined the role of a …

Cancer is a significant global health concern, and finding effective methods to treat it has
been a focus of scientific research. It has been discovered that the growth, invasion, and …

The purinergic P2X7 receptor is an ATP-gated cation channel expressed by various immune
and tumor cells. Expression of P2X7 by tumor cells can favor tumor growth by raising …

Highlights•Tumor bearing P2X7R null mice show increased and better performing
Treg.•Chemotactic gradient established by P2X7R ligands favors tumor infiltration by …