Dystrophinopathy and sarcoglycanopathies are incurable diseases caused by mutations in
the genes encoding dystrophin or members of the dystrophin associated protein complex …

Highlights•Inflammation is a pathological hallmark of muscular dystrophies.•Dystrophin
and/or sarcoglycans loss alter eATP degradation and P2X7 signalling in muscles.•Treatment …

Muscular dystrophies are inherited neuromuscular diseases, resulting in progressive
disability and often affecting life expectancy. The most severe, common types are Duchenne …

Background Duchenne muscular dystrophy (DMD) is the most common inherited muscle
disease, leading to severe disability and death in young men. Death is caused by the …

Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease leading
to severe disability and death of young men. Current interventions are palliative as no …

Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological
characteristics of DMD skeletal muscles include, among others, abnormal Ca2+ …

Sarcoglycanopathies, limb-girdle muscular dystrophies (LGMD) caused by genetic loss-of-
function of the membrane proteins sarcoglycans (SGs), are characterized by progressive …

Limb-girdle muscular dystrophy R3, a rare genetic disorder affecting the limb proximal
muscles, is caused by mutations in the α-sarcoglycan gene (Sgca) and aggravated by an …

Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in
Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly …

Following molecular and immunohistochemical analysis of the purinergic P2X4 receptor
subunit in dystrophin-deficient muscle we have identified a distinct subpopulation of P2X4 …