[HTML][HTML] Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora

P Yang, S Huang, Z Luo, S Zhou, C Zhang… - Biomedicine & …, 2024 - Elsevier
Schizophrenia (SCZ) is a psychotic mental disorder characterized by cognitive, behavioral,
and social impairments. However, current pharmacological treatment regimens are subpar …

Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/JAK-STAT signaling pathway

Y Long, Y Wang, Y Shen, J Huang, Y Li, R Wu, J Zhao - BMC psychiatry, 2023 - Springer
Background Abnormal activation of microglia is involved in the pathogenesis of
schizophrenia. Minocycline and antipsychotics have been reported to be effective in …

Spirulina platensis reduces the schizophrenic-like symptoms in rat model by restoring altered APO-E and RTN-4 protein expression in prefrontal cortex

S Haider, S Shahzad, Z Batool, S Sadir, L Liaquat… - Life Sciences, 2021 - Elsevier
Aims Schizophrenia (SZ) is recognized as a neuropsychiatric disorder in humans with
accelerated mortality and profound morbidity followed with impairments in social as well as …

Inulin ameliorates schizophrenia via modulation of the gut microbiota and anti-inflammation in mice

L Guo, P Xiao, X Zhang, Y Yang, M Yang, T Wang… - Food & function, 2021 - pubs.rsc.org
The microbiome–gut–brain (MGB) axis, which regulates neurological and cognitive
functions, plays an essential role in schizophrenia (SCZ) progression. Dietary inulin could …

[HTML][HTML] Rhubarb ameliorates cognitive dysfunction in a rat model of Alzheimer's disease through regulation of the intestinal microbiome

H Zhao, D Gao, X Gao - Journal of Traditional Chinese Medical Sciences, 2019 - Elsevier
Objective To determine the mechanism whereby rhubarb (Rheum tanguticum MAXIM. Ex
BALF.) may ameliorate cognitive dysfunction through regulation of the intestinal microbiome …

Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia

B Ben-Azu, AO Aderibigbe, AM Ajayi, AEO Eneni… - International …, 2019 - Elsevier
Neuroinflammation plays a prominent role in the pathophysiology and progression of
schizophrenia. Thus, suppression of neuroinflammation may retard the progression of the …

Antidepressant effects of rosemary extracts associate with anti-inflammatory effect and rebalance of gut microbiota

Y Guo, J Xie, X Li, Y Yuan, L Zhang, W Hu… - Frontiers in …, 2018 - frontiersin.org
It is currently believed that inflammation acts as a central part in the pathophysiology of
depression. Rosemary extracts (RE), the crucial active constituents extracted from …

Schisandra chinensis ameliorates depressive‐like behaviors by regulating microbiota‐gut‐brain axis via its anti‐inflammation activity

T Yan, N Wang, B Liu, B Wu, F Xiao… - Phytotherapy …, 2021 - Wiley Online Library
The present study aimed to examine the antidepressant actions of the composition fractions
of Schisandra chinensis using LPS‐induced mice. Animals were treated with total extracts …

Antidepression of Xingpijieyu formula targets gut microbiota derived from depressive disorder

Y Li, L Yang, J Li, W Gao, Z Zhao… - CNS neuroscience & …, 2023 - Wiley Online Library
Objective This investigation aims to determine the antidepressant role of Xingpijieyu formula
(XPJYF) mediated via gut microbiota (GM)–brain axis. Methods We collected fecal …

[HTML][HTML] Crocin alleviates schizophrenia-like symptoms in rats by upregulating silent information regulator-1 and brain derived neurotrophic factor

X Sun, X Zhao, J Xie, H Wan - Comprehensive Psychiatry, 2020 - Elsevier
Background In neonatal rats, MK-801 treatments can produce schizophrenia-like symptoms.
Crocin is a water soluble carotenoid in Saffron that exerts potent neuroprotective effects …