PURPOSE Evidence-based guidelines recommend cascade genetic counseling and testing
for hereditary cancer syndromes, providing relatives the opportunity for early detection and …

Simple Summary In general, 5–20% of all cancers are due to pathogenic variants in cancer
genes that are passed down in the family. It is recommended that blood relatives of …

The combination of increased referral for genetic testing and the current shortage of genetic
counselors has necessitated the development and implementation of alternative models of …

Evidence suggests that a significant proportion of individuals referred to cancer genetic
counselling (GC) do not attend, and thus may not be engaged in adequate cancer risk …

In cascade testing, genetic testing for an identified familial pathogenic variant extends to
disease-free relatives to allow genetically targeted disease prevention. We evaluated the …

Disclaimer: The practice guidelines of the American College of Medical Genetics and
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …

Purpose Family history of cancer (CFH) is important for identifying individuals to receive
genetic counseling/testing (GC/GT). Prior studies have demonstrated low rates of family …

Purpose To explore the readiness of living, untested first-degree relatives (FDRs) to have
cascade genetic testing (CGT) for a hereditary predisposition to cancer. Methods Adults with …

PURPOSE A powerful consequence of detecting cancer-associated pathogenic variants is
the ability to test at-risk relatives (ARRs), termed cascade testing. However, historical studies …

Advances in the application of genomic technologies in clinical care have the potential to
increase existing healthcare disparities. Studies have consistently shown that only a fraction …