[HTML][HTML] B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions

D Tan, W Yin, F Guan, W Zeng, P Lee… - Frontiers in Cell and …, 2022 - frontiersin.org
B cells are the core components of humoral immunity. A mature B cell can serve in multiple
capacities, including antibody production, antigen presentation, and regulatory functions …

Foxp3+ Treg cells in humoral immunity

JB Wing, S Sakaguchi - International immunology, 2014 - academic.oup.com
Treg cells are essential for the maintenance of immune homeostasis and prevention of
autoimmunity. In humoral immune responses, loss of Treg cell function causes increased …

[HTML][HTML] T follicular regulatory cells: choreographers of productive germinal center responses

Y Lu, J Craft - Frontiers in Immunology, 2021 - frontiersin.org
T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg)
cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge …

[HTML][HTML] Control of germinal center responses by T-follicular regulatory cells

JB Wing, M Tekgüç, S Sakaguchi - Frontiers in immunology, 2018 - frontiersin.org
Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential
role in the control of immune homeostasis. In order to control diverse types of immune …

Differentiation and function of Foxp3+ effector regulatory T cells

E Cretney, A Kallies, SL Nutt - Trends in immunology, 2013 - cell.com
Regulatory T (Treg) cells are essential for immunological tolerance and homeostasis.
Although forkhead box (Fox) p3 is continually required to reinforce the Treg cell program …

[HTML][HTML] Unexpected help: follicular regulatory T cells in the germinal center

MM Xie, AL Dent - Frontiers in immunology, 2018 - frontiersin.org
Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within
the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma …

T follicular cells: The regulators of germinal center homeostasis

F Ribeiro, E Perucha, L Graca - Immunology Letters, 2022 - Elsevier
The formation of high-affinity antibodies that protect against infection requires the formation
of germinal centres (GCs), where specialized T follicular helper cells (Tfh) provide help to B …

Control of foreign Ag‐specific Ab responses by Treg and Tfr

JB Wing, EL Lim, S Sakaguchi - Immunological reviews, 2020 - Wiley Online Library
Regulatory T cells (Tregs) expressing the transcription factor Foxp3 play a critical role in the
control of immune homeostasis including the regulation of humoral immunity. Recently, it …

Transcriptional regulation of Treg homeostasis and functional specification

K Wang, W Fu - Cellular and Molecular Life Sciences, 2020 - Springer
Abstract CD4+ Foxp3+ regulatory T (Treg) cells are key players in keeping excessive
inflammation in check. Mounting evidence has shown that Treg cells exert much more …

Regulatory T cells: molecular and cellular basis for immunoregulation

Y Togashi, H Nishikawa - … Targeting Immune Checkpoints in Cancer and …, 2017 - Springer
CD4+ regulatory T cells (Tregs) are a highly immune-suppressive subset of CD4+ T cells,
characterized by expression of the master regulatory transcription factor FOXP3. Tregs are …