Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to
drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been …

Although, the antiarrhythmic effect of amiodarone is well characterized, its effect on post-
ischemic heart and cardiomyocytes, as well as the mechanism of its toxicity on extracardiac …

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans.
It has previously been demonstrated that amiodarone and its metabolite …

The role played by oxidative stress in amiodarone-induced mitochondrial toxicity is debated.
Dronedarone shows pharmacological properties similar to those of amiodarone but several …

Amiodarone is a widely used and potent antiarrhythmic agent that is metabolized to
desethylamiodarone. Both amiodarone and its metabolite possess antiarrhythmic effect, and …

Dronedarone and amiodarone are structurally similar antiarrhythmic drugs. Dronedarone
worsens cardiac adverse effects with unknown causes while amiodarone has no cardiac …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …

Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Originally developed as an antianginal agent, amiodarone is now commonly prescribed as a
broad-spectrum antiarrhythmic. However, long-term treatment with this pharmaceutical is …

Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …