Mitochondria has an essential role in myocardial tissue homeostasis; thus deterioration in
mitochondrial function eventually leads to cardiomyocyte and endothelial cell death and …

Background Amiodarone (AMD) and its metabolite N-desethylamiodarone can cause some
adverse effects, which include pulmonary toxicity. Some studies suggest that mitochondrial …

Context: Amiodarone (an iodinated benzofuran) is a Class III antiarrhythmic drug that
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …

Background—Oxidative stress plays an important role in the pathophysiology of ischemic
heart disease and heart failure, and antioxidants might be beneficial in the treatment of …

Amiodarone is a potent anti-arrhythmic drug used for the treatment of cardiac arrhythmias.
Although, the effects of amiodarone are well characterized on post-ischemic heart and …

Background Cilostazol is a type 3 phosphodiesterase inhibitor which has been previously
demonstrated to prevent the occurrence of tachyarrhythmia and improve defibrillation …

The heart has an abundance of mitochondria since cardiac muscles require copious
amounts of energy for providing continuous blood through the circulatory system, thereby …

Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by
numerous adverse effects. Of greatest concern is AM-induced pulmonary toxicity (AIPT) due …

Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …

Kontogiannis et al. Mitochondria in β-adrenergic signaling mitochondria (7). Metoprolol was
later shown to inhibit β oxidation by downregulating carnitine palmitoyl-transferase I (8) …