It was previously shown that carvedilol, a β-adrenergic receptor antagonist with antioxidant
properties, was able to inhibit the mitochondrial permeability transition (MPT). In the present …

The critical role of mitochondria in cardiomyocyte survival and death has become an exciting
field of research in cardiac biology. Indeed, it is accepted that mitochondrial dysfunction …

In human atrial trabeculae, we examined the effects of doxorubicin on the isometric force of
contraction, mitochondrial respiration, membrane potential and calcium retention capacity …

Mitochondria are the most abundant organelles in cardiac cells, and are essential to
maintain the normal cardiac function, which requires mitochondrial dynamics and mitophagy …

Mitochondria are the energy powerhouses of cells and are essential for cell survival.
Evidence demonstrates that mitochondria are the off-targets of many drugs belonging to a …

Adrenergic receptors (ARs) are G protein–coupled receptors that are stimulated by
catecholamines to induce a wide array of physiological effects across tissue types. Both α1 …

BACKGROUND: The mechanisms underlying heart failure induced by adriamycin are very
complicated and still unclear. The aim of this study was to investigate whether autophagy …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

The effects of the antianginal and antiarrhythmic drug amiodarone on mitochondrial function
and high-energy phosphate content were assessed during normothermic ischaemic cardiac …

Mitochondria are one of the major sites for the generation of reactive oxygen species (ROS)
as an undesirable side product of oxidative energy metabolism. Damaged mitochondria can …