Sirt-1 is defined as a nuclear protein involved in the molecular mechanisms of inflammation
and neurodegeneration through the de-acetylation of many different substrates even if …

Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …

Abstract Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing
an important part in the pathogenesis and treatment of various disorders. They have …

Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Alzheimer's disease (AD) is the most prevalent cause of dementia in the aging population
worldwide. SIRT1 deacetylation of histones and transcription factors impinge on multiple …

Common environmental pollutants and drugs encountered in everyday life can cause toxic
damage to the body through oxidative stress, inflammatory stimulation, induction of …

Background. Recent studies suggest a correlation between the reduced Sirt‐1 expression
with Alzheimer's diseases (AD) and depression, respectively, suggesting a possible …

Background Sirt-1 is a NAD+-dependent nuclear deacetylase of 747 residues that in
mammals is involved in various important metabolic pathways, such as glucose metabolism …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

SIRT1, human ortholog of yeast SIR2 protein, deacetylates histones and several other
transcription factors. Recently, SIRT1 has emerged as a drug target for treating age related …