Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Background Genome-wide association studies (GWAS) have discovered genetic variants
that predispose individuals to asthma. To integrate these new discoveries with emerging …

Background Childhood-onset and adult-onset asthma differ with respect to severity and
comorbidities. Whether they also differ with respect to genetic risk factors has not been …

Asthma is a chronic and genetically complex respiratory disease that affects over 300 million
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …

Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

The first genome wide association study (GWAS) for childhood asthma identified a novel
major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role …

Background Research in transformed immortalized cell lines indicates the cadherin-related
family member 3 (CDHR3) protein serves as a receptor for human rhinovirus (HRV)–C …

Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the
same individuals, partly because of a shared genetic origin,,. To identify shared risk variants …

Asthma is a heterogeneous clinical syndrome that includes subtypes of disease with
different underlying causes and disease mechanisms. Asthma is caused by a complex …