Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure

S Kim, R Goel, A Kumar, Y Qi, G Lobaton… - Clinical …, 2018 - portlandpress.com
Recent evidence indicates a link between gut pathology and microbiome with hypertension
(HTN) in animal models. However, whether this association exists in humans is unknown …

Alterations in the gut microbiota can elicit hypertension in rats

S Adnan, JW Nelson, NJ Ajami… - Physiological …, 2017 - journals.physiology.org
Gut dysbiosis has been linked to cardiovascular diseases including hypertension. We tested
the hypothesis that hypertension could be induced in a normotensive strain of rats or …

Integrated Omic Analysis of Human Plasma Metabolites and Microbiota in a Hypertension Cohort

BY Chen, YL Li, WZ Lin, C Bi, LJ Du, Y Liu, LJ Zhou… - Nutrients, 2023 - mdpi.com
Hypertension is closely related to metabolic dysregulation, which is associated with
microbial dysbiosis and altered host–microbiota interactions. However, plasma metabolite …

Associations between peripheral blood microbiome and the risk of hypertension

Y Jing, H Zhou, H Lu, X Chen, L Zhou… - American Journal of …, 2021 - academic.oup.com
Background Although previous studies have reported the gut microbiome is closely related
to hypertension development, whether the change in blood microbiome is associated with …

The association between gut microbiome and hypertension varies according to enterotypes: a Korean study

JS Song, JOR Kim, SM Yoon, MJ Kwon… - Frontiers in …, 2023 - frontiersin.org
Several animal and clinical studies have reported that the state of the human gut
microbiome is associated with hypertension. In this study, we investigated the association …

[HTML][HTML] Sex differences in associations of plasma metabolites with blood pressure and heart rate variability: The HELIUS study

BJH Verhaar, CM Mosterd, D Collard, H Galenkamp… - Atherosclerosis, 2023 - Elsevier
Background and aims Since plasma metabolites can modulate blood pressure (BP) and
vary between men and women, we examined sex differences in plasma metabolite profiles …

Role of the microbiota in hypertension and antihypertensive drug metabolism

E Mishima, T Abe - Hypertension Research, 2022 - nature.com
Recent evidence suggests that the gut microbiota plays an important role in the
development and pathogenesis of hypertension. Dysbiosis, an imbalance in the composition …

Microbiome and hypertension: where are we now?

NG Vallianou, E Geladari… - Journal of Cardiovascular …, 2020 - journals.lww.com
Background Hypertension is the leading risk factor for cardiovascular disease and accounts
for approximately 9.4 million deaths globally every year. Hypertension is a complex entity …

Human stool metabolome differs upon 24 h blood pressure levels and blood pressure dipping status: a prospective longitudinal study

J Huart, A Cirillo, B Taminiau, J Descy, A Saint-Remy… - Metabolites, 2021 - mdpi.com
Dysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial
hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the …

[HTML][HTML] Intestinal microbiota: A promising therapeutic target for hypertension

D Sun, H Xiang, J Yan, L He - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Hypertension has developed into an escalating serious global public health problem with
multiple and unclear pathophysiological mechanisms. Recent studies have identified the …