Staphylococcal superantigens are pyrogenic exotoxins that cause massive T cell activation
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …

Staphylococcal enterotoxin B (SEB) and related superantigenic toxins produced by
Staphylococcus aureus are potent activators of the immune system. These protein toxins …

Staphylococcal exotoxins, staphylococcal enterotoxins AE (SEA-SEE), and toxic shock
syndrome toxin-1 (TSST-1) are potent activators of the immune system and cause a variety …

Microbial Superantigens are a family of protein exotoxins that share the ability to trigger
excessive and aberrant activation of T cells. The best characterised are the staphylococcal …

Exotoxins of Staphylococcus aureus belong to a family of bacterial proteins that act as
superantigens by activating a large subset of the T-cell population, causing massive release …

Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic
toxins produced by myriad microbes, are potent stimulators of the immune system causing a …

Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating
toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can …

Superantigens trigger an excessive cellular immune response, leading to toxic shock. We
have designed a peptide antagonist that inhibits superantigen-induced expression of human …

Bacterial superantigens are believed to cause septic shock, although, because of the lack of
superantigen-sensitive infection models, proof that superantigenicity underlies shock …