Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome
Staphylococcal superantigens are pyrogenic exotoxins that cause massive T cell activation
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
[HTML][HTML] Staphylococcal superantigens: pyrogenic toxins induce toxic shock
T Krakauer - Toxins, 2019 - mdpi.com
Staphylococcal enterotoxin B (SEB) and related superantigenic toxins produced by
Staphylococcus aureus are potent activators of the immune system. These protein toxins …
Staphylococcus aureus are potent activators of the immune system. These protein toxins …
Immune response to staphylococcal superantigens
T Krakauer - Immunologic research, 1999 - Springer
Staphylococcal exotoxins, staphylococcal enterotoxins AE (SEA-SEE), and toxic shock
syndrome toxin-1 (TSST-1) are potent activators of the immune system and cause a variety …
syndrome toxin-1 (TSST-1) are potent activators of the immune system and cause a variety …
Superantigens: microbial agents that corrupt immunity
M Llewelyn, J Cohen - The Lancet infectious diseases, 2002 - thelancet.com
Microbial Superantigens are a family of protein exotoxins that share the ability to trigger
excessive and aberrant activation of T cells. The best characterised are the staphylococcal …
excessive and aberrant activation of T cells. The best characterised are the staphylococcal …
Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists
RA Buonpane, HRO Churchill, B Moza, EJ Sundberg… - Nature medicine, 2007 - nature.com
Exotoxins of Staphylococcus aureus belong to a family of bacterial proteins that act as
superantigens by activating a large subset of the T-cell population, causing massive release …
superantigens by activating a large subset of the T-cell population, causing massive release …
[HTML][HTML] Staphylococcal superantigens spark host-mediated danger signals
T Krakauer, K Pradhan, BG Stiles - Frontiers in immunology, 2016 - frontiersin.org
Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic
toxins produced by myriad microbes, are potent stimulators of the immune system causing a …
toxins produced by myriad microbes, are potent stimulators of the immune system causing a …
Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production
Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …
Superantigens Subvert the Neutrophil Response To Promote Abscess Formation and Enhance Staphylococcus aureus Survival In Vivo
SX Xu, KJ Gilmore, PA Szabo, JJ Zeppa… - Infection and …, 2014 - Am Soc Microbiol
Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating
toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can …
toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can …
Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation
G Arad, R Levy, D Hillman, R Kaempfer - Nature medicine, 2000 - nature.com
Superantigens trigger an excessive cellular immune response, leading to toxic shock. We
have designed a peptide antagonist that inhibits superantigen-induced expression of human …
have designed a peptide antagonist that inhibits superantigen-induced expression of human …
Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice
S Sriskandan, M Unnikrishnan, T Krausz… - The Journal of …, 2001 - academic.oup.com
Bacterial superantigens are believed to cause septic shock, although, because of the lack of
superantigen-sensitive infection models, proof that superantigenicity underlies shock …
superantigen-sensitive infection models, proof that superantigenicity underlies shock …