Appropriate embryo-uterine interactions are essential for implantation. Besides oocyte
abnormalities, implantation failure is a major contributor to early pregnancy loss. Previously …

Women and other mammalian females are born with a finite supply of oocytes that
determine their reproductive lifespan. During fetal development, individual oocytes are …

Irx3 is a member of the Iroquois homeobox gene family that encodes a protein known for its
essential role in spinal cord development. Transcript screening of male and female gonads …

Healthy development of ovarian follicles depends on appropriate interactions and function
between oocytes and their surrounding granulosa cells. Previously, we showed that double …

Members of the Iroquois B (IrxB) homeodomain cluster genes, specifically Irx3 and Irx5, are
crucial for heart, limb and bone development. Recently, we reported their importance for …

The mouse decidua secretes many factors that act in a paracrine/autocrine manner to
critically control uterine decidualization, neovascularization, and tissue remodeling that …

Pig conceptuses secrete estrogen for pregnancy recognition, and they secrete interferons
(IFNs) gamma and delta during the peri-implantation period. The uterine effects of pig IFNs …

Background Recurrent implantation failure is a critical issue in IVF‐ET treatment. Successful
embryo implantation needs appropriate molecular and cellular communications between …

Decidualization, the process by which fibroblastic human endometrial stromal cells (HESC)
differentiate into secretory decidual cells, is a critical event during the establishment of …

The survival and development of a semi-allogeneic fetus during pregnancy require the
involvement of decidual stromal cells (DSCs), a series of cytokines and immune cells. Insulin …