Prostate cancer (PCa) is the most common non-skin cancer men in developed countries.
Despite years of research, no strong modifiable risk factor for PCa has been found. The two …

Recent genetics and genomics studies of prostate cancer have helped to clarify the genetic
basis of this common but complex disease. Genome-wide studies have detected numerous …

Purpose: We review the current epidemiological and genetic knowledge regarding
hereditary prostate cancer, and outline its clinical implications. Materials and Methods …

BACKGROUND Currently used prognostic markers are limited in their ability to accurately
predict disease progression among patients with localized prostate cancer. We examined 23 …

The search for susceptibility loci in hereditary prostate cancer (HPC) has proven challenging
due to genetic and disease heterogeneity. Multiple risk loci have been identified to date …

Genome-wide association studies (GWAS) have identified 76 variants associated with
prostate cancer risk predominantly in populations of European ancestry. To identify …

Background Family history of prostate cancer (PCa) is a well-known risk factor, and both
common and rare genetic variants are associated with the disease. Objective To detect new …

Purpose: Although prostate-specific antigen (PSA) is the best biomarker for predicting
prostate cancer, its predictive performance needs to be improved. Results from the Prostate …

A recent genome-wide association study found that genetic variants on chromosomes 3, 6,
7, 10, 11, 19 and X were associated with prostate cancer risk. We evaluated the most …

BACKGROUND Although the subject of intensive study, the genetic influences responsible
for familial clustering of prostate cancer remain largely unidentified. Genome‐wide scans for …