Th1 cytokine endotype discriminates and predicts severe complications in COVID-19

T Hasegawa, T Hato, T Okayama, K Ikeo… - European Cytokine …, 2022 - Springer
Abstract Treatment of severe and critical cases of coronavirus disease 2019 (COVID-19) is
still a top priority in public health. Previously, we reported distinct Th1 cytokines related to …

Heightened circulating interferon-inducible chemokines, and activated pro-cytolytic Th1-cell phenotype features covid-19 aggravation in the second week of illness

C Tincati, ES Cannizzo, M Giacomelli… - Frontiers in …, 2020 - frontiersin.org
Covid-19 features a delayed onset of critical illness occurring approximately one week from
the beginning of symptoms, which corresponds to the bridging of innate and adaptive …

Plasma cytokine atlas reveals the importance of TH2 polarization and interferons in predicting COVID-19 severity and survival

L Gibellini, S De Biasi, M Meschiari, L Gozzi… - Frontiers in …, 2022 - frontiersin.org
Although it is now widely accepted that host inflammatory response contributes to COVID-19
immunopathogenesis, the pathways and mechanisms driving disease severity and clinical …

[HTML][HTML] Type 1 inflammatory endotype relates to low compliance, lung fibrosis, and severe complications in COVID-19

T Hasegawa, A Nakagawa, K Suzuki, K Yamashita… - Cytokine, 2021 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19) is an acute respiratory disease;
approximately 5% of patients developing severe COVID-19. It is known that cytokine release …

Cytokine Signatures and Immune Dysregulation in COVID-19 Patients: Transcriptomic and Serum Analysis

N Ralchev, SL Bradyanova, YV Doneva… - Journal of Interferon & …, 2024 - liebertpub.com
COVID-19, caused by the SARS-CoV-2 virus, has caused a global health crisis,
necessitating a deeper understanding of its pathophysiology. In this study, we explored the …

Th1/Th2/Th17 cytokine profile among different stages of COVID-19 infection

G Gupta, I Shareef, S Tomar, MSN Kumar… - National Academy …, 2022 - Springer
Abstract Aim To characterize Th1/Th2/Th17 cytokine profile (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-
γ, and IL-17A) among different stages of COVID-19 infection. Methods This was a cross …

Cytokine signature and COVID-19 prediction models in the two waves of pandemics

S Cabaro, V D'Esposito, T Di Matola, S Sale… - Scientific Reports, 2021 - nature.com
In Europe, multiple waves of infections with SARS-CoV-2 (COVID-19) have been observed.
Here, we have investigated whether common patterns of cytokines could be detected in …

An early Th1 response is a key factor for a favorable COVID-19 evolution

FJ Gil-Etayo, S Garcinuño, A Utrero-Rico… - Biomedicines, 2022 - mdpi.com
The Th1/Th2 balance plays a crucial role in the progression of different pathologies and is a
determining factor in the evolution of infectious diseases. This work has aimed to evaluate …

[HTML][HTML] Imbalance of T Helper cell subset specific transcription factors and associated cytokines in patients with severe COVID-19

P Gupta, K Patel, G Garg, BJ Mathew, D Kale… - Gene …, 2023 - xiahepublishing.com
Methods We assessed T helper cell responses in SARS-CoV-2 infected individuals who
presented with either asymptomatic, mild, or severe disease. mRNA profiling of lineage …

Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19

NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …