Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to
orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well …

Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival
rates of all cancers. The bone marrow microenvironment is increasingly being recognised as …

The bone marrow is the home of hematopoiesis and is therefore a hotspot for the
development of hematopoietic diseases. Complex interactions between the bone marrow …

Objectives: To summarize the effects of the bone marrow niche on hematopoiesis and
leukemogenesis and discuss the chemotherapy resistance that can arise from interactions …

In recent decades, the conduct of uniform prospective clinical trials has led to improved
remission rates and survival for patients with acute myeloid leukaemia and acute …

Murine models of myeloid neoplasia show how leukemia infiltration alters the hematopoietic
stem cell (HSC) niche to reinforce malignancy at the expense of healthy hematopoiesis …

The bone marrow (BM) microenvironment regulates the properties of healthy hematopoietic
stem cells (HSCs) localized in specific niches. Two distinct microenvironmental niches have …

Despite individual differences between certain leukemias, the overall survival rate in acute
leukemia remains low at approximately 40%. Novel therapeutics, including targeted …

Acute myeloid leukemias (AML) comprise a wide array of different entities, which have in
common a rapid expansion of myeloid blast cells leading to displacement of normal …

Abstract Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically
heterogeneous set of diseases, which are characterised by an increased growth of …