Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

What is known and objective Obesity is a significant burden on the healthcare system in the
U nited S tates, and determining the appropriate antimicrobial dosing regimen in morbidly …

As obesity continues to increase in prevalence throughout the world, it becomes important to
explore the effects that obesity has on antimicrobial disposition. Physiologic changes in …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

Although the dose of some drugs is commonly adjusted for weight, weight-related dosage
adjustments are rarely made for most antimicrobials. We reviewed the English-language …

Obesity causes a number of changes, including an increase in volume of distribution and
changes in hepatic metabolism and renal excretion. Several antibiotics have sufficient data …

Purpose Obesity, a major health issue, is also an important risk factor for infections.
Evidence demonstrates that excess weight affects the disposition of antibiotics but little work …

Objectives: Obesity may alter the pharmacokinetics of β-lactams. The goal of this study was
to evaluate if and why serum concentrations are inadequate when standard β-lactam …

Obesity is associated with physiological changes that can alter the pharmacokinetic
parameters of many drugs. Vancomycin and the aminoglycosides are the only antibacterials …

Background The prevention of healthcare-associated infections (HCAIs) is a major goal in
modern healthcare. Intrinsic, patient-related factors may contribute to the risk of HCAIs. Aim …