Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

The pathogenesis of sepsis-associated acute kidney injury is complex and likely involves
perfusion alterations, a dysregulated inflammatory response, and bioenergetic …

Despite identification of several cellular mechanisms being thought to underlie the
development of septic acute kidney injury (AKI), the pathophysiology of the occurrence of …

Objectives: To determine whether there is a decrease in renal cortical or medullary perfusion
and oxygenation in a conscious large animal model of hyperdynamic septic shock with …

Acute kidney injury (AKI) is a major burden on health systems and may arise from multiple
initiating insults, including ischaemia‐reperfusion injury, cardiovascular surgery …

AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …

Sepsis is the commonest cause of acute kidney injury in critically ill patients. Its
pathophysiology is complex and not well understood. Until recently, it was believed that …

The renal microcirculation plays a major role in the delivery of blood and oxygen to the
kidney. In sepsis, alterations in renal microvascular perfusion, in conjunction with increased …

Given that the leading clinical conditions associated with acute kidney injury (AKI), namely,
sepsis, major surgery, heart failure, and hypovolemia, are all associated with shock, it is …

Acute kidney injury (AKI) remains one of the main causes of morbidity and mortality in the
intensive care medicine today. Its pathophysiology and progress to chronic kidney disease …