Background: Despite increased understanding of the pathophysiology of septic acute kidney
injury (AKI), treatment options are limited, and mortality remains high. Summary: Septic AKI …

Acute kidney injury (AKI) is a serious multifactorial conditions accompanied by the loss of
function and damage. The renal microcirculation plays a crucial role in maintaining the …

In experimental sepsis, the rapid development of renal medullary hypoxia precedes the
development of acute kidney injury (AKI) and may contribute to its pathogenesis. We …

Acute kidney injury (AKI) is a frequent complication in the intensive care unit with limited
therapeutic modalities. Although survival from isolated AKI has improved with recent …

Sepsis is considered today a major public health problem. Despite that mortality has been
consistently associated with organ compromise, the mechanisms by which sepsis causes …

Sepsis is a complex clinical syndrome characterized by a systemic inflammatory response to
an infective insult. This process often leads to widespread tissue injury and multiple organ …

Sepsis-induced acute kidney injury (AKI) is the most common form of AKI observed in
critically ill patients. AKI mortality in septic critically ill patients remains high despite our …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

For a long time, acute kidney injury (AKI) was considered to be a primarily hemodynamic
condition characterized by a reduction of renal blood flow, induced by either cardiogenic or …

Acute kidney injury (AKI) represents a sudden reduction in renal function and is a major
clinical problem with a high mortality rate. Despite decades of research, there are currently …