Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

There is growing evidence that impairment in intrarenal oxygenation and hypoxic injury
might contribute to the pathogenesis of septic renal failure. An important molecule known to …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

The pathophysiology of sepsis-induced acute kidney injury remains poorly understood. As
changes in renal perfusion and oxygenation have been shown, we aimed to study the short …

The kidney is a common “victim organ” of various insults in critically ill patients. Sepsis and
septic shock are the dominant causes of acute kidney injury, accounting for nearly 50% of …

The pathogenesis of sepsis-induced acute kidney injury (AKI) is not fully understood, and
may involve altered systemic hemodynamics and renal circulation, renal hypoxia and …

The availability of oxygen in renal tissue is determined by the complex interactions among a
host of processes, including renal blood flow, glomerular filtration, arterial-to-venous oxygen …

The ability to produce a concentrated urine is imposed by a uniquely low ambient oxygen
pressure in the renal medulla due to shunt diffusion within the vascular bundles. As the thick …

Septic acute kidney injury (AKI) is the most common form of AKI seen in critically ill patients
in developed countries. Its pathogenesis has been traditionally attributed to ischemia …

One of the most frequent and serious complications to develop in septic patients is acute
kidney injury (AKI), a disorder characterized by a rapid failure of the kidneys to adequately …