Background Aspergillus fumigatus has to cope with a combination of several stress types
while colonizing the human body. A functional interplay between these different stress …

Background Aspergillus fumigatus is a ubiquitous airborne fungal pathogen that presents a
life-threatening health risk to individuals with weakened immune systems. A. fumigatus …

NADPH-oxidase mediated production of Reactive Oxygen Species (ROS) by alveolar
macrophages and neutrophils is a critical mechanism for immune defence against …

Background Aspergillus fumigatus is a mold responsible for the majority of cases of
aspergillosis in humans. To survive in the human body, A. fumigatus must adapt to …

Aspergillus fumigatus is an important fungal pathogen that causes allergic reactions but also
life-threatening infections. One of the most abundant A. fumigatus proteins is Asp f3. This …

Iron plays a critical role in survival and virulence of the opportunistic pathogen Aspergillus
fumigatus. Two transcription factors, the GATA-factor SreA and the bZip-factor HapX …

The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by
upregulation of iron uptake mechanisms including siderophore biosynthesis and …

Microorganisms have to adapt their metabolism to the requirements of their ecological niche
to avoid iron shortage as well as iron toxicity. Therefore, mechanisms have been evolved to …

Iron is an essential but, in excess, toxic nutrient. Therefore, fungi evolved fine-tuned
mechanisms for uptake and storage of iron, such as the production of siderophores (low …

The saprophytic fungus Aspergillus fumigatus is the most prevalent airborne fungal
pathogen, which is responsible for invasive aspergillosis in immunocompromised patients …