Aberrant B cell signaling plays a critical in role in various systemic and organ-specific
autoimmune diseases. This is supported by genetic evidence by many functional studies in …

B-cell activation factor from the tumor necrosis factor family (BAFF) is a key survival factor
during B-cell maturation—a delicate immune checkpoint for B cells. Excessive BAFF …

Highlights•BAFF signaling increases metabolic capacity.•Components of the alternative
NFκB pathway govern metabolic reprogramming.•BAFF impacts autophagy and redox …

The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL
(a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess …

BAFF [B‐cell activating factor belonging to the tumor necrosis factor (TNF) family] is a ligand
that is required for peripheral B‐cell survival and homeostasis. In addition to mediating B …

A hallmark of thymus-dependent immunity is the generation of long-lived humoral immune
responses. The production of long-lived memory B cells (Bmem) and plasma cells (PCs) …

B cells require signals from multiple sources for their development from precursor cells, and
differentiation into effector cells. BAFF has been identified as a critical regulator of B cell …

B lymphocytes contribute to immunity through production of antibodies, antigen presentation
to T cells, and secretion of cytokines. B cells are generally considered in autoimmune …

Autoantibodies contribute to the development of systemic lupus erythematosus (SLE). APRIL
(a proliferation‐inducing ligand), a member of the TNF superfamily, regulates plasma‐cell …

B cell activating factor (BAFF) is a crucial survival factor for transitional and mature B cells,
and is a promising therapeutic target for systemic lupus erythematosus (SLE). A BAFF …