B cells play important roles in normal immunity and human disease. While much has been
learned from elegant studies utilizing genetically modified mice or with immunotherapy in …

BAFF (B lymphocyte activating factor of the tumour necrosis factor family) is a vital
homeostatic cytokine for B cells that helps regulate both innate and adaptive immune …

It is increasingly recognized that B cells have multiple functions that contribute to the
pathogenesis of autoimmunity. Specific targeting of B cells might therefore be an appropriate …

Autoimmunity results from a break in self-tolerance involving humoral and/or cell-mediated
immune mechanisms. One pathological consequence of a failure in central and/or …

The role of BAFF in B cell self tolerance was examined by tracking the fate of anti-HEL self-
reactive B cells in BAFF transgenic mice using four different models of self-reactive B cell …

B cells play a pivotal role in autoimmunity not only by producing pathogenic autoantibodies
but also by modulating immune responses via the production of cytokines and chemokines …

B lymphocyte stimulator (BLyS; also known as B cell activating factor (BAFF)) plays a key
role in peripheral B cell tolerance. Mounting evidence indicates that B cell tolerance can be …

B cells play a pivotal role in the pathogenesis of autoimmune disease (AD) by the production
of autoantibodies, secretion of cytokines and presentation of autoantigens. As a pro-survival …

The BAFF system plays a key role in the development of autoimmunity, especially in
systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly …

The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF)
availability influences selection of the autoreactive B-cell repertoire in NZB/W and …