Unexpected development of autoimmunity in BAFF‐R‐mutant MRL‐lpr mice

ZL Ju, GY Shi, JX Zuo, JW Zhang, Jian Sun - Immunology, 2007 - Wiley Online Library
BAFF‐R is the predominant receptor that mediates B‐cell activating factor (BAFF)‐
dependent B‐cell signalling and plays a critical role in late‐stage B‐cell maturation and …

BAFF and rheumatic autoimmune disorders: implications for disease management and therapy

S Bosello, JO Pers, C Rochas… - International journal …, 2007 - journals.sagepub.com
Interest in B-cells has been revived due to the description of new functions. Supporting a
role for B-cells in the genesis of autoimmune diseases is the fact that the B-cell activating …

Activating systemic autoimmunity: B's, T's, and tolls

MJ Shlomchik - Current opinion in immunology, 2009 - Elsevier
A recent advance in the treatment and understanding of autoimmune disease has been the
efficacy of B-cell-targeted therapy. Such therapies are effective for several such diseases …

[HTML][HTML] Intracellular B lymphocyte signalling and the regulation of humoral immunity and autoimmunity

TE Taher, J Bystrom, VH Ong, DA Isenberg… - Clinical reviews in …, 2017 - Springer
B lymphocytes are critical for effective immunity; they produce antibodies and cytokines,
present antigens to T lymphocytes and regulate immune responses. However, because of …

Signalling pathways in B cells: implications for autoimmunity

T Dörner, PE Lipsky - Current Concepts in Autoimmunity and Chronic …, 2006 - Springer
Following investigations of the pathogenic role of autoantibodies in rheumatic diseases,
preclinical and clinical studies suggest a more central role of B cells in the maintenance of …

The late news on baff in autoimmune diseases

P Youinou, JO Pers - Autoimmunity reviews, 2010 - Elsevier
The B cell-activating factor of the tumor-necrosis factor family (BAFF) plays a dominant role
in the B cell homeostasis. By rescuing autoreactive B cells, excessive BAFF favors the …

Targeting BAFF in autoimmunity

A Davidson - Current opinion in immunology, 2010 - Elsevier
BAFF and APRIL are TNF-like cytokines that support survival and differentiation of B cells.
The early appreciation that overexpression of BAFF leads to B cell expansion and a lupus …

The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity

MP Cancro - Annals of the rheumatic diseases, 2006 - ard.bmj.com
The B lymphocyte stimulator (BLyS; also termed BAFF) family of ligands and receptors plays
a central role in B lymphocyte development, selection, and homoeostasis. Members of this …

Signaling mechanisms regulating B-lymphocyte activation and tolerance

E Hobeika, PJ Nielsen, D Medgyesi - Journal of Molecular Medicine, 2015 - Springer
It is becoming more and more accepted that, in addition to producing autoantibodies, B
lymphocytes have other important functions that influence the development of autoimmunity …

Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation

J Kim, JA Gross, SR Dillon, JK Min, KB Elkon - Autoimmunity, 2011 - Taylor & Francis
B lymphocyte stimulator (BLyS) and APRoliferation inducing ligand (APRIL) are members of
the TNF superfamily that regulate B-cell survival and autoreactivity. To further understand …