Recently, the B cell has emerged as a cornerstone of systemic lupus erythematosus (SLE)
pathogenesis. This has been highlighted by studies of the cytokine B‐cell‐activating factor of …

BAFF‐R is the predominant receptor that mediates B‐cell activating factor (BAFF)‐
dependent B‐cell signalling and plays a critical role in late‐stage B‐cell maturation and …

Interest in B-cells has been revived due to the description of new functions. Supporting a
role for B-cells in the genesis of autoimmune diseases is the fact that the B-cell activating …

A recent advance in the treatment and understanding of autoimmune disease has been the
efficacy of B-cell-targeted therapy. Such therapies are effective for several such diseases …

B lymphocytes are critical for effective immunity; they produce antibodies and cytokines,
present antigens to T lymphocytes and regulate immune responses. However, because of …

Following investigations of the pathogenic role of autoantibodies in rheumatic diseases,
preclinical and clinical studies suggest a more central role of B cells in the maintenance of …

The B cell-activating factor of the tumor-necrosis factor family (BAFF) plays a dominant role
in the B cell homeostasis. By rescuing autoreactive B cells, excessive BAFF favors the …

BAFF and APRIL are TNF-like cytokines that support survival and differentiation of B cells.
The early appreciation that overexpression of BAFF leads to B cell expansion and a lupus …

The B lymphocyte stimulator (BLyS; also termed BAFF) family of ligands and receptors plays
a central role in B lymphocyte development, selection, and homoeostasis. Members of this …

It is becoming more and more accepted that, in addition to producing autoantibodies, B
lymphocytes have other important functions that influence the development of autoimmunity …