Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Sepsis-Induced Acute Kidney Injury by Promoting Mitophagy of Renal Tubular Epithelial Cells via the …

J Guo, R Wang, D Liu - Frontiers in endocrinology, 2021 - frontiersin.org
Sepsis is a common risk factor for acute kidney injury (AKI). Bone marrow-derived
mesenchymal stem cells (BMSCs) bear multi-directional differentiation potential. This study …

Placental mesenchymal stem cells alleviate podocyte injury in diabetic kidney disease by modulating mitophagy via the SIRT1-PGC-1alpha-TFAM pathway

X Han, J Wang, R Li, M Huang, G Yue, L Guan… - International Journal of …, 2023 - mdpi.com
The use of mesenchymal stem cells (MSCs) has become a new strategy for treating diabetic
kidney disease (DKD). However, the role of placenta derived mesenchymal stem cells (P …

A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway

S Wang, C Zhang, S Niyazi, L Zheng, J Li… - Journal of translational …, 2017 - Springer
Background Mesenchymal stem cell (MSC) has been widely explored in the past decade as
a cell-based treatment for various diseases. However, poor survival of adaptively transferred …

[HTML][HTML] Bone marrow mesenchymal stem cells repair Cr (VI)-injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK …

F Yin, J Yan, Y Zhao, KJ Guo, ZL Zhang, AP Li… - Ecotoxicology and …, 2019 - Elsevier
The present study aimed to explore the repair effect and mechanism of bone marrow
mesenchymal stem cells (BMSCs) transplantation on injured kidneys caused by hexavalent …

Biological membrane-packed mesenchymal stem cells treat acute kidney disease by ameliorating mitochondrial-related apoptosis

X Geng, Q Hong, W Wang, W Zheng, O Li, G Cai… - Scientific reports, 2017 - nature.com
The mortality of rhabdomyolysis-induced AKI remains high because no effective therapy
exists. We investigated a new therapeutic method using MSCs. The aim of this study was to …

Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy

WC Tseng, PY Lee, MT Tsai, FP Chang… - Stem Cell Research & …, 2021 - Springer
Background Acute kidney injury (AKI) is an emerging global healthcare issue without
effective therapy yet. Autophagy recycles damaged organelles and helps maintain tissue …

Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK

Z Xie, J Tang, Z Chen, L Wei, J Chen, Q Liu - Inflammation Research, 2023 - Springer
Objective Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs)
have been demonstrated as a potential therapeutic agent in acute kidney injury (AKI) …

Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC-1α …

Y Yuan, L Yuan, L Li, F Liu, J Liu, Y Chen, J Cheng… - Stem Cells, 2021 - academic.oup.com
Mesenchymal stem cells (MSCs) have fueled ample translation for treatment of immune-
mediated diseases. Our previous study had demonstrated that MSCs could elicit …

Bone marrow‐derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion‐induced lung injury

J Li, J Zhou, D Zhang, Y Song, J She… - Journal of cellular and …, 2015 - Wiley Online Library
Autophagy, a type II programmed cell death, is essential for cell survival under stress, eg
lung injury, and bone marrow‐derived mesenchymal stem cells (BM‐MSC s) have great …

The regulation of inflammatory mediators in acute kidney injury via exogenous mesenchymal stem cells

T Du, YJ Zhu - Mediators of inflammation, 2014 - Wiley Online Library
Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity.
Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous …